Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor

• Xianzhi Chai,
• Hai-Hao Han,
• Yi Zang,
• Jia Li,
• Xiao-Peng He,
• Junji Zhang and
• He Tian

Beilstein J. Org. Chem. 2019, 15, 2380–2389, doi:10.3762/bjoc.15.230

• photoswitchable imaging of intracellular glutathione (GSH). The photochromic glycosheet manifests significantly turn-on fluorescence and dynamic ON/OFF fluorescence signals in response to GSH, which makes it favorable for intracellular GSH double-check in targeted human hepatoma cell line (HepG2) through the

• therapy. Keywords: intracellular GSH; molecular switches; photochromic glycosheet; photoswitchable imaging; 2D MnO2 nanosheets; Introduction Cells are the basic structure and functional unit of biological organisms. Human diseases and aging are closely related to the states of cells. Thorough

• design and further broaden the availability of photoswitchable biosensing, herein we report a glycosheet hybrid sensor (Glyco-DTE@MnO2) fabricated by 2D MnO2 nanosheets and dithienylethene fluorescence reporter (Glyco-DTE) to achieve cell-targeted photoswitchable imaging of intracellular GSH. As shown in